Dangers of Insufficient Breastfeeding Presented at the First Coast Neonatal Symposium

Dr. Christie del Castillo-Hegyi was invited to present her research on the brain- and life-threatening consequences of insufficient feeding of exclusively breastfed newborns at the First Coast Neonatal Symposium held by the Department of Neonatology at the University of Florida at Jacksonville on April 24, 2017.  Here is the video of the lecture presented.

Note: A segment of the lecture was excluded due to copyright laws and will be posted once permission is granted to publish it.

References for Dangers of Insufficient Breastfeeding Presented at the First Coast Neonatal Symposium, April 24, 2017, University of Florida, Jacksonville

1: Marchini G, Persson B, Berggren V, Hagenäs L. Hunger behaviour contributes to
early nutritional homeostasis. Acta Paediatr. 1998 Jun;87(6):671-5. PubMed PMID:
9686661.

2: Nommsen-Rivers LA, Heinig MJ, Cohen RJ, Dewey KG. Newborn wet and soiled
diaper counts and timing of onset of lactation as indicators of breastfeeding
inadequacy. J Hum Lact. 2008 Feb;24(1):27-33. doi: 10.1177/0890334407311538.
PubMed PMID: 18281353

3: Yamane J, Ishibashi S, Sakaguchi M, Kuroiwa T, Kanemura Y, Nakamura M, Miyoshi
H, Sawamoto K, Toyama Y, Mizusawa H, Okano H. Transplantation of human neural
stem/progenitor cells overexpressing galectin-1 improves functional recovery from
focal brain ischemia in the Mongolian gerbil. Mol Brain. 2011 Sep 27;4:35. doi:
10.1186/1756-6606-4-35. PubMed PMID: 21951913; PubMed Central PMCID: PMC3215926.

4: Zhou D, Qian J, Liu CX, Chang H, Sun RP. Repetitive and profound
insulin-induced hypoglycemia results in brain damage in newborn rats: an approach
to establish an animal model of brain injury induced by neonatal hypoglycemia.
Eur J Pediatr. 2008 Oct;167(10):1169-74. doi: 10.1007/s00431-007-0653-2. Epub
2008 Jan 17. PubMed PMID: 18205012.

5: Burns CM, Rutherford MA, Boardman JP, Cowan FM. Patterns of cerebral injury
and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia.
Pediatrics. 2008 Jul;122(1):65-74. doi: 10.1542/peds.2007-2822. PubMed PMID:
18595988.

6: Chang RJ, Chou HC, Chang YH, Chen MH, Chen CY, Hsieh WS, Tsao PN. Weight loss
percentage prediction of subsequent neonatal hyperbilirubinemia in exclusively
breastfed neonates. Pediatr Neonatol. 2012 Feb;53(1):41-4. doi:
10.1016/j.pedneo.2011.11.008. Epub 2012 Jan 17. PubMed PMID: 22348493.

7: Yang WC, Zhao LL, Li YC, Chen CH, Chang YJ, Fu YC, Wu HP. Bodyweight loss in
predicting neonatal hyperbilirubinemia 72 hours after birth in term newborn
infants. BMC Pediatr. 2013 Sep 21;13:145. doi: 10.1186/1471-2431-13-145. PubMed
PMID: 24053490; PubMed Central PMCID: PMC3849505.

8: Bertini G, Dani C, Tronchin M, Rubaltelli FF. Is breastfeeding really favoring
early neonatal jaundice? Pediatrics. 2001 Mar;107(3):E41. PubMed PMID: 11230622.

9: Ben XM. Nutritional management of newborn infants: practical guidelines. World
J Gastroenterol. 2008 Oct 28;14(40):6133-9. Review. PubMed PMID: 18985802; PubMed
Central PMCID: PMC2761573.

10: Gidrewicz DA, Fenton TR. A systematic review and meta-analysis of the
nutrient content of preterm and term breast milk. BMC Pediatr. 2014 Aug
30;14:216. doi: 10.1186/1471-2431-14-216. Review. PubMed PMID: 25174435; PubMed
Central PMCID: PMC4236651.

11: Neville MC, Keller R, Seacat J, Lutes V, Neifert M, Casey C, Allen J, Archer
P. Studies in human lactation: milk volumes in lactating women during the onset
of lactation and full lactation. Am J Clin Nutr. 1988 Dec;48(6):1375-86. PubMed
PMID: 3202087.

12: Academy of Breastfeeding Medicine Protocol Committee.. ABM clinical protocol
#3: hospital guidelines for the use of supplementary feedings in the healthy term
breastfed neonate, revised 2009. Breastfeed Med. 2009 Sep;4(3):175-82. doi:
10.1089/bfm.2009.9991. Erratum in: Breastfeed Med. 2011 Jun;6(3):159. PubMed
PMID: 19739952.

13: Flaherman VJ, Schaefer EW, Kuzniewicz MW, Li SX, Walsh EM, Paul IM. Early
weight loss nomograms for exclusively breastfed newborns. Pediatrics. 2015
Jan;135(1):e16-23. doi: 10.1542/peds.2014-1532. Epub 2014 Dec 1. PubMed PMID:
25554815; PubMed Central PMCID: PMC4279066.

14: Dewey KG, Nommsen-Rivers LA, Heinig MJ, Cohen RJ. Risk factors for suboptimal
infant breastfeeding behavior, delayed onset of lactation, and excess neonatal
weight loss. Pediatrics. 2003 Sep;112(3 Pt 1):607-19. PubMed PMID: 12949292.

15: Young PC, Korgenski K, Buchi KF. Early readmission of newborns in a large
health care system. Pediatrics. 2013 May;131(5):e1538-44. doi:
10.1542/peds.2012-2634. Epub 2013 Apr 8. PubMed PMID: 23569092.

16: Greco C, Arnolda G, Boo NY, Iskander IF, Okolo AA, Rohsiswatmo R, Shapiro SM,
Watchko J, Wennberg RP, Tiribelli C, Coda Zabetta CD. Neonatal Jaundice in Low-
and Middle-Income Countries: Lessons and Future Directions from the 2015 Don
Ostrow Trieste Yellow Retreat. Neonatology. 2016;110(3):172-80. doi:
10.1159/000445708. Epub 2016 May 14. PubMed PMID: 27172942.

17: Olusanya BO, Osibanjo FB, Mabogunje CA, Slusher TM, Olowe SA. The burden and
management of neonatal jaundice in Nigeria: A scoping review of the literature.
Niger J Clin Pract. 2016 Jan-Feb;19(1):1-17. doi: 10.4103/1119-3077.173703.
PubMed PMID: 26755212.

18: Olusanya BO, Ogunlesi TA, Kumar P, Boo NY, Iskander IF, de Almeida MF,
Vaucher YE, Slusher TM. Management of late-preterm and term infants with
hyperbilirubinaemia in resource-constrained settings. BMC Pediatr. 2015 Apr
12;15:39. doi: 10.1186/s12887-015-0358-z. PubMed PMID: 25884679; PubMed Central
PMCID: PMC4409776.

19: Saint L, Smith M, Hartmann PE. The yield and nutrient content of colostrum
and milk of women from giving birth to 1 month post-partum. Br J Nutr. 1984
Jul;52(1):87-95. PubMed PMID: 6743645.

20. Hoa DP, Thanh HT, Höjer B, Persson LA. Young child feeding in a rural area in the Red River delta, Vietnam. Acta Paediatr. 1995 Sep;84(9):1045-9. PubMed PMID: 8652957.

21. Srivastava SP, Sharma VK, Kumar V. Breast feeding pattern in neonates. Indian Pediatr. 1994 Sep;31(9):1079-82. PubMed PMID: 7883365.

22. Semega-Janneh IJ, Bøhler E, Holm H, Matheson I, Holmboe-Ottesen G. Promoting breastfeeding in rural Gambia: combining traditional and modern knowledge. Health Policy Plan. 2001 Jun;16(2):199-205. PubMed PMID: 11358922.

23. Davies-Adetugbo AA. Sociocultural factors and the promotion of exclusive breastfeeding in rural Yoruba communities of Osun State, Nigeria. Soc Sci Med. 1997 Jul;45(1):113-25. PubMed PMID: 9203276.

24. Delport SD, Bergh AM, Hay IT. Breast-feeding practices in a private maternity hospital. S Afr Med J. 1988 Oct 15;74(8):396-9. PubMed PMID: 3187818.

25. Kumar S, Nath LM, Reddaiah VP. Breast feeding practices in a resettlement colony and its implications for promotional activities. Indian J Pediatr. 1989 Mar-Apr;56(2):239-42. PubMed PMID: 2807451.

25. .Islam MA, Nielsen CC. Maternal and child health services: evaluating mothers’ perceptions and participation. Public Health. 1993 Jul;107(4):243-9. PubMed PMID: 8356206.

26. Ashraf RN, Jalil F, Khan SR, Zaman S, Karlberg J, Lindblad BS, Hanson LA. Early child health in Lahore, Pakistan: V. Feeding patterns. Acta Paediatr Suppl.1993 Aug;82 Suppl 390:47-61. PubMed PMID: 8219467.

27. Akuse RM, Obinya EA. Why healthcare workers give prelacteal feeds. Eur J Clin
Nutr. 2002 Aug;56(8):729-34. PubMed PMID: 12122548.

28. 11: Neville MC, Keller R, Seacat J, Lutes V, Neifert M, Casey C, Allen J, Archer
P. Studies in human lactation: milk volumes in lactating women during the onset
of lactation and full lactation. Am J Clin Nutr. 1988 Dec;48(6):1375-86. PubMed
PMID: 3202087.

29. Bergman NJ. Neonatal stomach volume and physiology suggest feeding at 1-h
intervals. Acta Paediatr. 2013 Aug;102(8):773-7. doi: 10.1111/apa.12291. Epub
2013 Jun 3. Review. PubMed PMID: 23662739.

30. Samayam P, Ranganathan PK, Kotari UD, Balasundaram R. Study of Asymptomatic
Hypoglycemia in Full Term Exclusively Breastfed Neonates in First 48 Hours of
Life. J Clin Diagn Res. 2015 Sep;9(9):SC07-10. doi: 10.7860/JCDR/2015/14971.6610.
Epub 2015 Sep 1. PubMed PMID: 26500974; PubMed Central PMCID: PMC4606303.

31. Tam EW, Haeusslein LA, Bonifacio SL, Glass HC, Rogers EE, Jeremy RJ,
Barkovich AJ, Ferriero DM. Hypoglycemia is associated with increased risk for
brain injury and adverse neurodevelopmental outcome in neonates at risk for
encephalopathy. J Pediatr. 2012 Jul;161(1):88-93. doi:
10.1016/j.jpeds.2011.12.047. Epub 2012 Feb 4. PubMed PMID: 22306045; PubMed
Central PMCID: PMC3346850.

32. Kaiser JR, Bai S, Gibson N, Holland G, Lin TM, Swearingen CJ, Mehl JK,
ElHassan NO. Association Between Transient Newborn Hypoglycemia and Fourth-Grade
Achievement Test Proficiency: A Population-Based Study. JAMA Pediatr. 2015
Oct;169(10):913-21. doi: 10.1001/jamapediatrics.2015.1631. PubMed PMID: 26301959.

33. Seske LM, Merhar SL, Haberman BE. Late-Onset Hypoglycemia in Term Newborns
With Poor Breastfeeding. Hosp Pediatr. 2015 Sep;5(9):501-4. doi:
10.1542/hpeds.2015-0086. PubMed PMID: 26330250.

34. Burns CM, Rutherford MA, Boardman JP, Cowan FM. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia.
Pediatrics. 2008 Jul;122(1):65-74. doi: 10.1542/peds.2007-2822. PubMed PMID:
18595988.

35. McKinlay CJ, Alsweiler JM, Ansell JM, Anstice NS, Chase JG, Gamble GD, Harris
DL, Jacobs RJ, Jiang Y, Paudel N, Signal M, Thompson B, Wouldes TA, Yu TY,
Harding JE; CHYLD Study Group.. Neonatal Glycemia and Neurodevelopmental Outcomes
at 2 Years. N Engl J Med. 2015 Oct 15;373(16):1507-18. doi:
10.1056/NEJMoa1504909. PubMed PMID: 26465984; PubMed Central PMCID: PMC4646166.

36. Thornton PS, Stanley CA, De Leon DD, Harris D, Haymond MW, Hussain K,
Levitsky LL, Murad MH, Rozance PJ, Simmons RA, Sperling MA, Weinstein DA, White
NH, Wolfsdorf JI; Pediatric Endocrine Society.. Recommendations from the
Pediatric Endocrine Society for Evaluation and Management of Persistent
Hypoglycemia in Neonates, Infants, and Children. J Pediatr. 2015
Aug;167(2):238-45. doi: 10.1016/j.jpeds.2015.03.057. Epub 2015 May 6. PubMed
PMID: 25957977.

37. Okumus N, Turkyilmaz C, Onal EE, Atalay Y, Serdaroglu A, Elbeg S, Koc E, Deda
G, Cansu A, Gunduz B. Tau and S100B proteins as biochemical markers of
bilirubin-induced neurotoxicity in term neonates. Pediatr Neurol. 2008
Oct;39(4):245-52. doi: 10.1016/j.pediatrneurol.2008.07.004. PubMed PMID:
18805362.

38. Hokkanen L, Launes J, Michelsson K. Adult neurobehavioral outcome of
hyperbilirubinemia in full term neonates-a 30 year prospective follow-up study.
PeerJ. 2014 Mar 4;2:e294. doi: 10.7717/peerj.294. eCollection 2014. PubMed PMID:
24688870; PubMed Central PMCID: PMC3961148

37. Tam EW, Haeusslein LA, Bonifacio SL, Glass HC, Rogers EE, Jeremy RJ, Barkovich
AJ, Ferriero DM. Hypoglycemia is associated with increased risk for brain injury
and adverse neurodevelopmental outcome in neonates at risk for encephalopathy. J
Pediatr. 2012 Jul;161(1):88-93. doi: 10.1016/j.jpeds.2011.12.047. Epub 2012 Feb
4. PubMed PMID: 22306045; PubMed Central PMCID: PMC3346850.

38. Vanhorebeek I, Gielen M, Boussemaere M, Wouters PJ, Grandas FG, Mesotten D,
Van den Berghe G. Glucose dysregulation and neurological injury biomarkers in
critically ill children. J Clin Endocrinol Metab. 2010 Oct;95(10):4669-79. doi:
10.1210/jc.2010-0805. Epub 2010 Jul 28. PubMed PMID: 20668035.

39. Bhutani VK, Johnson-Hamerman L. The clinical syndrome of bilirubin-induced
neurologic dysfunction. Semin Fetal Neonatal Med. 2015 Feb;20(1):6-13. doi:
10.1016/j.siny.2014.12.008. Epub 2015 Jan 7. Review. PubMed PMID: 25577653.

40. Sarici D, Gunes T, Yazici C, Akin MA, Korkmaz L, Memur S, Kurtoglu S, Ozturk
MA, Sarici SU. Investigation on malondialdehyde, S100B, and advanced oxidation
protein product levels in significant hyperbilirubinemia and the effect of
intensive phototherapy on these parameters. Pediatr Neonatol. 2015
Apr;56(2):95-100. doi: 10.1016/j.pedneo.2014.06.006. Epub 2014 Sep 26. PubMed
PMID: 25261050.

41. Pediatr Neurol. 2008 Oct;39(4):245-52. doi: 10.1016/j.pediatrneurol.2008.07.004.
Tau and S100B proteins as biochemical markers of bilirubin-induced neurotoxicity in term neonates.
Okumus N1, Turkyilmaz C, Onal EE, Atalay Y, Serdaroglu A, Elbeg S, Koc E, Deda G, Cansu A, Gunduz B.

42. PeerJ. 2014 Mar 4;2:e294. doi: 10.7717/peerj.294. eCollection 2014.
Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates-a 30 year prospective follow-up study. Hokkanen L1, Launes J1, Michelsson K1.

43. Kuzniewicz MW, Greene DN, Walsh EM, McCulloch CE, Newman TB. Association
Between Laboratory Calibration of a Serum Bilirubin Assay, Neonatal Bilirubin
Levels, and Phototherapy Use. JAMA Pediatr. 2016 Jun 1;170(6):557-61. doi:
10.1001/jamapediatrics.2015.4944. PubMed PMID: 27064480.

44. Koklu E, Gunes T, Ozturk MA, Kose M, Kurtoglu S, Yuksel F. A review of 116
cases of breastfeeding-associated hypernatremia in rural area of central Turkey.
J Trop Pediatr. 2007 Oct;53(5):347-50. Epub 2007 May 12. PubMed PMID: 17496322.

45. Uras N, Karadag A, Dogan G, Tonbul A, Tatli MM. Moderate hypernatremic
dehydration in newborn infants: retrospective evaluation of 64 cases. J Matern
Fetal Neonatal Med. 2007 Jun;20(6):449-52. PubMed PMID: 17674254.

46. Eidelman AI. Breastfeeding and the use of human milk: an analysis of the
American Academy of Pediatrics 2012 Breastfeeding Policy Statement. Breastfeed
Med. 2012 Oct;7(5):323-4. Epub 2012 Sep 4. PubMed PMID: 22946888.

47. Yang WC, Zhao LL, Li YC, Chen CH, Chang YJ, Fu YC, Wu HP. Bodyweight loss in
predicting neonatal hyperbilirubinemia 72 hours after birth in term newborn
infants. BMC Pediatr. 2013 Sep 21;13:145. doi: 10.1186/1471-2431-13-145. PubMed
PMID: 24053490; PubMed Central PMCID: PMC3849505.

48. Escobar GJ, Liljestrand P, Hudes ES, Ferriero DM, Wu YW, Jeremy RJ, Newman TB.
Five-year neurodevelopmental outcome of neonatal dehydration. J Pediatr. 2007
Aug;151(2):127-33, 133.e1. PubMed PMID: 17643761; PubMed Central PMCID:
PMC2233705.

49. Academy of Breastfeeding Medicine Protocol Committee.. ABM clinical protocol
#3: hospital guidelines for the use of supplementary feedings in the healthy term
breastfed neonate, revised 2009. Breastfeed Med. 2009 Sep;4(3):175-82. doi:
10.1089/bfm.2009.9991. Erratum in: Breastfeed Med. 2011 Jun;6(3):159. PubMed
PMID: 19739952.

50 Wight N, Marinelli KA; Academy of Breastfeeding Medicine.. ABM clinical
protocol #1: guidelines for blood glucose monitoring and treatment of
hypoglycemia in term and late-preterm neonates, revised 2014. Breastfeed Med.
2014 May;9(4):173-9. doi: 10.1089/bfm.2014.9986. PubMed PMID: 24823918; PubMed
Central PMCID: PMC4026103.

51. Committee on Fetus and Newborn., Adamkin DH. Postnatal glucose homeostasis in
late-preterm and term infants. Pediatrics. 2011 Mar;127(3):575-9. doi:
10.1542/peds.2010-3851. Epub 2011 Feb 28. Review. PubMed PMID: 21357346.

52. Hawdon JM, Beer J, Sharp D, Upton M; NHS Improvement Patient Safety Programme
‘Reducing Term Admissions to Neonatal Units’.. Neonatal hypoglycaemia: learning
from claims. Arch Dis Child Fetal Neonatal Ed. 2017 Mar;102(2):F110-F115. doi:
10.1136/archdischild-2016-310936. Epub 2016 Aug 23. PubMed PMID: 27553590; PubMed
Central PMCID: PMC5339558.

53. Fed is Best Feeding Plan – http://fedisbest.org/resources-for-parents/feeding-plan/

54. Stanford Medicine – Hand Expression of Breastmilk https://med.stanford.edu/newborns/professional-education/breastfeeding/hand-expressing-milk.html

55. Jensen D, Wallace S, Kelsay P. LATCH: a breastfeeding charting system and
documentation tool. J Obstet Gynecol Neonatal Nurs. 1994 Jan;23(1):27-32. PubMed
PMID: 8176525.

56. Nommsen-Rivers LA, Heinig MJ, Cohen RJ, Dewey KG. Newborn wet and soiled
diaper counts and timing of onset of lactation as indicators of breastfeeding
inadequacy. J Hum Lact. 2008 Feb;24(1):27-33. doi: 10.1177/0890334407311538.
PubMed PMID: 18281353.

57. Wei, C.-C., Chang, C.-H., Lin, C.-L., Chang, S.-N., Li, T.-C., and Kao, C.-H. (2015). Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study. J Child Psychol Psychiatry 56, 460–467.

58. Hokkanen, L., Launes, J., and Michelsson, K. (2014). Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates—a 30 year prospective follow-up study. PeerJ 2, e294.

59. Maimburg, R.D., Olsen, J., and Sun, Y. (2016). Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. Epilepsy Research 124, 67–72.

60. Gourley, G.R. (2002). Breast-feeding, neonatal jaundice and kernicterus. Semin Neonatol 7, 135–141.
61. Duan, G., Yao, M., Ma, Y., and Zhang, W. (2014). Perinatal and background risk factors for childhood autism in central China. Psychiatry Res 220, 410–417.

62. Newborn weight loss tool – https://www.newbornweight.org/

63. Hasan J, Khan Z, Sinha SN. Socio-cultural factors influencing nutritional
status of infants — a longitudinal study. Indian J Matern Child Health.
1991;2(3):84-6. PubMed PMID: 12346054.

64. Academy of Breastfeeding Medicine Protocol Committee.. ABM clinical protocol
#22: guidelines for management of jaundice in the breastfeeding infant equal to
or greater than 35 weeks’ gestation. Breastfeed Med. 2010 Apr;5(2):87-93. PubMed
PMID: 20387269.

2 thoughts on “Dangers of Insufficient Breastfeeding Presented at the First Coast Neonatal Symposium

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.